Protests in Iran are entering their third week as tens of thousands continue to take to the streets despite a deadly crackdown. President Trump said the death toll "appears significant," and Western officials say at least 2,000 have been killed. That would make these protests the deadliest since the 1979 revolution, and analysts say they could threaten the regime itself. Nick Schifrin reports.

In our news wrap Tuesday, inflation held mostly steady in December as prices rose 2.7% compared to a year before, Bill and Hillary Clinton are refusing to testify in a congressional investigation of Jeffrey Epstein and Gaza officials say at least four people are dead after strong winds knocked over walls and destroyed makeshift shelters.

Across the Justice Department, there was a wave of resignations from top prosecutors. At least four senior leaders of the division that investigates police killings have resigned in protest over the handling of the fatal shooting of a woman in Minneapolis by an ICE officer. In Minnesota, six other federal prosecutors have left their posts. Amna Nawaz discussed more with Carol Leonnig.

A hotly debated political issue made its way to the U.S. Supreme Court. At issue is whether transgender athletes should be allowed to compete in women's sports. The conservative majority seemed skeptical of striking down bans already in place in over half of all states. Liz Landers has a closer look at the legal and political fight before the nation's highest court.

Crucial talks are due to take place in Washington between Vice President JD Vance, Secretary of State Marco Rubio and the foreign ministers of Denmark and Greenland. President Trump has coveted the Danish territory, and his repeated threats to take over the island have prompted warnings that such a move could lead to the breakup of NATO. Malcolm Brabant reports from Copenhagen.